Emerging Diagnostic and Therapeutic Tools for CNS Infections
This Viewpoint discusses 2 next-generation approaches to diagnosis and therapy that are either already clinically relevant or likely to be tested in central nervous system neurotropic viral infections...
View ArticleDiagnosis of Sporadic Creutzfeldt-Jakob Disease Using Prion Protein
This cross-sectional study assesses the feasibility of sporadic Creutzfeldt-Jakob disease diagnosis by adaptation of an established variant Creutzfeldt-Jakob disease diagnostic blood test to urine.
View ArticleCongenital Zika Virus Infection
This case series describes the prenatal evolution and perinatal outcomes of 11 neonates who had developmental abnormalities and neurological damage associated with maternal Zika virus infection in...
View ArticleZika Virus—A Public Health Emergency of International Concern
In 1982, the late father of neurovirology, Richard T. Johnson, wrote:
View ArticleHepatitis E Virus–Associated Guillain-Barré Syndrome
This cohort study assesses the prevalence of hepatitis E virus–associated Guillain-Barré syndrome in a Belgian cohort as well as the clinical spectrum of hepatitis E virus–associated Guillain-Barré...
View ArticleHepatitis E Virus and Guillain-Barré Syndrome
A century ago when Guillain, Barré, and Strohl described the acute inflammatory polyneuropathic syndrome (Guillain-Barré syndrome [GBS]) for which they are still eponymously remembered, they noted...
View ArticleHuman Prion Disease Diagnosis Using RT-QuIC Testing
This case-control study assesses an algorithm for diagnosis of Creutzfeldt-Jakob disease using cerebrospinal fluid and olfactory mucosa samples among patients with possible, probable, or suspected...
View ArticleLaboratory Diagnosis of Sporadic Creutzfeldt-Jakob Disease
The report by Bongianni et al in this issue of JAMA Neurology compares the results of cerebrospinal fluid (CSF) and nasal brushings as samples for the detection of misfolded prion protein using the...
View ArticleHepatitis E Virus–Associated Guillain-Barré Syndrome
This cohort study assesses the prevalence of hepatitis E virus–associated Guillain-Barré syndrome in a Belgian cohort as well as the clinical spectrum of hepatitis E virus–associated Guillain-Barré...
View ArticleHepatitis E Virus and Guillain-Barré Syndrome
A century ago when Guillain, Barré, and Strohl described the acute inflammatory polyneuropathic syndrome (Guillain-Barré syndrome [GBS]) for which they are still eponymously remembered, they noted...
View ArticleIntracranial Tuberculoma in a Patient With Human Immunodeficiency Virus
This case report describes a woman in her 40s who was admitted after 4 months of headache, fatigue, and weight loss.
View ArticleSites of John Cunningham Virus Persistence
This retrospective study determines sites of JCV persistence in immunologically healthy individuals.
View ArticleA Woman in Her 60s With Chronic Meningitis
This case report describes the process of determining which pathogen caused a woman in her 60s to present with symptoms of chronic meningitis.
View ArticleIntracranial Tuberculoma in a Patient With Human Immunodeficiency Virus
This case report describes a woman in her 40s who was admitted after 4 months of headache, fatigue, and weight loss.
View ArticleHIV Presenting as Progressive Multifocal Leukoencephalopathy
A man in his 50s with an unremarkable medical history began experiencing vertigo 1 week after a viral upper respiratory tract infection.
View ArticleMultiple Spinal Lesions in an Immunocompetent Young Man
A 30-year-old man was referred with progressive quadriplegia that started from the right lower limb and gradually spread to the upper limb and contralateral side. Cerebrospinal fluid testing revealed...
View ArticleEnhanced Epilepsy Surveillance and Awareness in the Age of Zika
This Viewpoint argues for enhanced seizure and epilepsy awareness and surveillance in infants with congenital ZIKV exposure.
View ArticleHIV Presenting as Progressive Multifocal Leukoencephalopathy
A man in his 50s with an unremarkable medical history began experiencing vertigo 1 week after a viral upper respiratory tract infection.
View ArticleMultiple Spinal Lesions in an Immunocompetent Young Man
A 30-year-old man was referred with progressive quadriplegia that started from the right lower limb and gradually spread to the upper limb and contralateral side. Cerebrospinal fluid testing revealed...
View ArticleCerebrospinal Fluid Examination in Survivors of Ebola Virus Disease
This cohort study assesses the role of the central nervous system as a potential reservoir for Ebola virus after initial clinical recovery in a population of patients who survived Ebola virus disease.
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