Neurologists The Last Bedside Physician-Scientists Neurologists
Over the course of nearly 40 years in medicine, I have had the opportunity to see an evolution in the practice of medicine. As a medical student, I remember that my colleagues and I worked very hard to...
View ArticleElevated CSF Cytokines in the Jarisch-Herxheimer Reaction of General Paresis...
ImportanceThe Jarisch-Herxheimer reaction (JHR) is a well-recognized transient worsening of signs and symptoms occurring soon after the first dose of an appropriate antibiotic for several spirochetal...
View ArticleBlind and Confused Blind and Confused Blind and Confused
A 62-year-old man developed confusion and was diagnosed as having encephalitis. The etiology was not identified. He continued to have cognitive impairment but remained clinically stable. Five months...
View ArticleVascular Complications of Fungal Meningitis Attributed to Injections of...
ImportanceFungal meningitis due to injections of contaminated methylprednisolone acetate can present with vascular sequelae in immunocompetent individuals. This is particularly germane to neurologists...
View ArticleTherapeutic Decisions in Multiple Sclerosis Moving Beyond Efficacy...
Several innovative disease-modifying treatments (DMTs) for relapsing-remitting multiple sclerosis have been licensed recently or are in late-stage development. The molecular targets of several of these...
View ArticleShould CLIPPERS Be Considered a Prelymphoma State or a New Inflammatory Disease?
To the Editor We read with interest the clinical observation titled “Fatal B-cell lymphoma following chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids...
View ArticleVascular Complications of Fungal Meningitis Attributed to Injections of...
ImportanceFungal meningitis due to injections of contaminated methylprednisolone acetate can present with vascular sequelae in immunocompetent individuals. This is particularly germane to neurologists...
View ArticleReversible Pure Word Deafness
A 29-year-old right-handed human immunodeficiency virus (HIV)–seropositive (CD4 lymphocyte nadir, 7/mm3) woman commenced antiretroviral therapy (emtricitabine, 200 mg; tenofovir, 300 mg; and efavirenz,...
View ArticleIndicators of Central Fever in the Neurologic Intensive Care Unit
ImportanceFever is common in critically ill neurologic patients. Knowledge of the indicators of central fever may allow greater antibiotic stewardship in this era of rapidly developing super-resistant...
View ArticleOculomotor Nerve Palsy as the Presenting Symptom of Gummatous Neurosyphilis...
A 39-year-old man presented with 5 months of worsening right eyelid ptosis, fatigue, and diplopia, which progressed to include anorexia, low-grade fevers, and arthralgias. An examination revealed a...
View ArticleRecurrence of Coccidioidal Meningitis After Discontinuation of Fluconazole
A 53-year-old woman with a history of coccidioidal meningitis discontinued her long-term suppressive fluconazole following normal head computed tomography (Figure 1A) and cerebrospinal fluid...
View ArticleHerpes Simplex Encephalitis as a Potential Cause of Anti– N -Methyl- d...
ImportanceEncephalitis mediated by anti–N-methyl-d-aspartate (NMDA) receptor antibodies and herpes simplex (HS) encephalitis are seemingly separate causes of encephalopathy in adults and children....
View ArticleJC Polyomavirus Granule Cell Neuronopathy in a Patient Treated With Rituximab
ImportanceProgressive multifocal leukoencephalopathy results from lytic infection of the glia by the JC polyomavirus (JCV); JCV granule cell neuronopathy is caused by infection with a mutated form of...
View ArticleSwitching From Natalizumab to Fingolimod in Multiple Sclerosis A French...
ImportanceThe safety and efficacy of switching from natalizumab to fingolimod have not yet been evaluated in a large cohort of patients with multiple sclerosis (MS) to our knowledge.ObjectiveTo collect...
View ArticleHerpes Simplex Encephalitis as a Potential Cause of Anti– N -Methyl- d...
ImportanceEncephalitis mediated by anti–N-methyl-d-aspartate (NMDA) receptor antibodies and herpes simplex (HS) encephalitis are seemingly separate causes of encephalopathy in adults and children....
View ArticleTransverse Myelitis Plus Syndrome and Acute Disseminated Encephalomyelitis...
ImportanceClassically, transverse myelitis and acute disseminated encephalomyelitis are considered central nervous system demyelinating conditions. In both conditions, the spinal cord is involved to...
View ArticleJC Virus in CD34 + and CD19 + Cells in Patients With Multiple Sclerosis...
ImportanceInfection with JC virus (JCV) may lead to development of demyelinating progressive multifocal leukoencephalopathy in patients with multiple sclerosis (MS) who are treated with...
View ArticleSwitching From Natalizumab to Fingolimod in Multiple Sclerosis A French...
ImportanceThe safety and efficacy of switching from natalizumab to fingolimod have not yet been evaluated in a large cohort of patients with multiple sclerosis (MS) to our knowledge.ObjectiveTo collect...
View ArticleJC Polyomavirus Granule Cell Neuronopathy in a Patient Treated With Rituximab
ImportanceProgressive multifocal leukoencephalopathy results from lytic infection of the glia by the JC polyomavirus (JCV); JCV granule cell neuronopathy is caused by infection with a mutated form of...
View ArticleJC Virus in CD34 + and CD19 + Cells in Patients With Multiple Sclerosis...
ImportanceInfection with JC virus (JCV) may lead to development of demyelinating progressive multifocal leukoencephalopathy in patients with multiple sclerosis (MS) who are treated with...
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